Why the study?
Heart disease remains the leading cause of death worldwide, and previous therapeutic strategies targeting Cx43 were non-specific with many off-target effects.
Specific peptides targeting Connexin 43 hemichannels represent a promising new therapeutic avenue for myocardial ischemia and ventricular arrhythmias.
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Smet et al. (2022) conducted a review in Myocardial ischemia and ventricular arrhythmia. Peptides targeting Connexin 43 channel function was evaluated.
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