Key result
Chronic atrial fibrillation increases Pitx2c expression in human atrial myocytes, which positively correlates with IKs density and negatively correlates with ICa,L density.
Observational
Pitx2c is upregulated in chronic atrial fibrillation and may drive electrical remodeling by altering potassium and calcium currents.
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Pitx2c may modulate atrial ion currents in chronic AF; hypothesis-generating for targeted interventions pending in vivo validation.
Pérez-Hernández et al. (2015) conducted an observational in Chronic atrial fibrillation. Chronic atrial fibrillation vs. Sinus rhythm was evaluated on Pitx2c mRNA expression and correlation with IKs and ICa,L densities. Chronic atrial fibrillation increases Pitx2c expression in human atrial myocytes, which positively correlates with IKs density and negatively correlates with ICa,L density.
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