Key result
Calcium-activated chloride current blockade (60% of nominal) inhibited alternans generation induced by increasing pace rate in a simulated rabbit atrial action potential model.
Why the study?
Does I_Cl,Ca blockade inhibit alternans of atrial action potentials in a rabbit atrial model?
Does I_Cl,Ca blockade inhibit alternans of atrial action potentials in a rabbit atrial model?
Simulation results suggest that blocking calcium-activated chloride currents could play an antiarrhythmogenic role by inhibiting atrial action potential alternans.
I_Cl,Ca blockade may suppress atrial alternans in rabbit models; leaves open antiarrhythmic translation to humans.
Atrial fibrillation (AF) is a common cardiac arrhythmia. The appearance of alternans of atrial action potential (AP) during atrial flutter could play a determinant role as a precursor of AF. The ionic basis for these beat-to-beat changes in AP involves intracellular calcium cycling in the maintenance of alternans. Alterations of intracellular calcium concentration affect to calcium dependent currents like I/sub NaCa/ and I/sub Cl,Ca/. In this study, a modified rabbit atrial AP model, that includes I/sub Cl,Ca/ formulation, is used. Alternans generation was induced by increasing pace rate (from a cycle length of 1000 to 180 ms). In this situation, our results show that I/sub Cl,Ca/ blockade (60% of nominal) inhibits alternans. It suggests that I/sub Cl,Ca/ blockade could play an important antiarrhythmogenic role.
No takes yet. Share an insight, caveat, or question.
Gomis-Tena et al. (2004) studied Atrial fibrillation. Calcium-activated chloride current (I/sub Cl,Ca/) blockade was evaluated on Alternans generation. Calcium-activated chloride current blockade (60% of nominal) inhibited alternans generation induced by increasing pace rate in a simulated rabbit atrial action potential model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: