Key result
Elevated systolic blood pressure and pulse pressure were significantly associated with increased risk of mild cognitive impairment and cognitive loss (p<0.01 for trend).
Why the study?
Whether blood pressure and what level of controlled blood pressure reduces the risk of cognitive impairment remained uncertain.
Does elevated blood pressure increase the risk of cognitive impairment and dementia in older women?
Population
7207 community-dwelling women aged 65-79 years across 39 US clinical centres
Comparison
Hypertension, SBP, and PP strata vs controlled levels or normotension
Design
Prospective cohort study
Follow-up
Median 9 years (IQR 6-15)
Authors
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Supports BP monitoring in older women; leaves open whether intensive control reduces cognitive risk pending trials.
Cohort (n=7,207)
Yes
Does elevated blood pressure increase the risk of cognitive impairment and dementia in older women?
Hazard Ratio: 1.33 (95% CI 0.98–1.82)
p-value: p=0.071
Elevated systolic blood pressure and pulse pressure are associated with an increased risk of mild cognitive impairment and cognitive loss in older women, suggesting intensive BP control may preserve cognitive health.
Liu et al. (2022) conducted a cohort in Cognitive impairment and dementia (n=7,207). Hypertension, elevated systolic blood pressure, and pulse pressure vs. Normotension was evaluated on Mild cognitive impairment (HR 1.33, 95% CI 0.98-1.82, p=0.071). Elevated systolic blood pressure and pulse pressure were significantly associated with increased risk of mild cognitive impairment and cognitive loss (p<0.01 for trend).
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