Key result
Elevated systolic blood pressure (≥160 mmHg) in women aged 76-80 years was associated with a five-fold increased risk of executive function impairment over 9 years (HR 5.05).
Why the study?
Does elevated systolic blood pressure or pulse pressure increase the risk of cognitive impairment in older non-demented women?
Population
336 non-demented community-dwelling female participants aged 70-80 years in the Women's Health and Aging…
Comparison
Elevated systolic blood pressure or elevated… vs Normal and pre-hypertensive SBP or low PP
Design
Cohort
Follow-up
maximum 9 years
Authors
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May flag cognitive risk in older women with high SBP/PP; leaves open causal effects and need for prospective confirmation.
Cohort (n=337)
No
Does elevated systolic blood pressure or pulse pressure increase the risk of cognitive impairment in older non-demented women?
Hazard Ratio: 5.05 (95% CI 1.42–18.04)
Elevated systolic blood pressure and pulse pressure in older women are associated with an increased risk of late-life cognitive impairment, suggesting pulse pressure could be a useful risk assessment tool.
Yaşar et al. (2011) conducted a cohort in Cognitive Impairment (n=337). Elevated systolic blood pressure (≥160 mmHg) vs. Normal and pre-hypertensive SBP (≤139 mmHg) was evaluated on Incidence of impairment on Trail Making Test-Part B (TMT, Part B) in participants aged 76-80 years (HR 5.05, 95% CI 1.42-18.04). Elevated systolic blood pressure (≥160 mmHg) in women aged 76-80 years was associated with a five-fold increased risk of executive function impairment over 9 years (HR 5.05).
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