Key result
Volume loading in septic shock patients with initial PWP lower than CVP significantly increased blood pressure from 94.4 to 118.9 mm Hg without deteriorating pulmonary oxygenating capacity.
Why the study?
Does volume loading improve hemodynamics without deteriorating pulmonary oxygenating capacity in patients with septic shock?
Population
20 patients with clinical and bacteriological evidence of generalized sepsis (septic shock).
Comparison
Volume loading (intravenous fluid administration). vs Patients were compared based on their initial…
Design
Cohort
Follow-up
24 hours
Authors
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Supports PWP-CVP monitoring to identify fluid responders in septic shock; leaves open randomized confirmation of benefit.
Cohort (n=20)
Does volume loading improve hemodynamics without deteriorating pulmonary oxygenating capacity in patients with septic shock?
Synchronous monitoring of PWP and CVP in septic shock helps identify patients who will respond favorably to fluid loading without respiratory deterioration.
Krausz et al. (1977) conducted a cohort in Septic shock (n=20). Volume loading vs. Patients with initial PWP higher than CVP was evaluated on Hemodynamic response (blood pressure, PWP, cardiac output). Volume loading in septic shock patients with initial PWP lower than CVP significantly increased blood pressure from 94.4 to 118.9 mm Hg without deteriorating pulmonary oxygenating capacity.
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