Why the study?
Does cardiac sympathetic stimulation or noradrenaline cause coronary vasoconstriction after myocardial beta-adrenoceptor blockade with practolol?
Does cardiac sympathetic stimulation or noradrenaline cause coronary vasoconstriction after myocardial beta-adrenoceptor blockade with practolol?
Blockade of myocardial beta-adrenoceptors by practolol unmasks coronary vasoconstriction in response to sympathetic stimulation or noradrenaline, likely via alpha-adrenoceptors.
May unmask alpha-mediated coronary vasoconstriction after beta-blockade in animals; leaves open translation to human coronary physiology.
After blockade of myocardial, but not coronary vascular beta-adrenoceptors by practolol, cardiac sympathetic stimulation or exogenously administered noradrenaline gave rise to coronary vasoconstriction, possibly due to stimulation of coronary alpha-adrenoceptors.
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Adam et al. (1970) studied this question.
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