Why the study?
Does intravenous practolol alter haemodynamics in patients with acute myocardial infarction?
Does intravenous practolol alter haemodynamics in patients with acute myocardial infarction?
Intravenous practolol reduces heart rate and cardiac output without affecting stroke volume during the acute phase of myocardial infarction.
Supports cautious practolol use with monitoring in acute MI; extends early beta-blocker observations but leaves open randomized confirmation.
The haemodynamic effect of practolol, a cardioselective beta-adrenergic receptor blocker, has been studied in I8 patients during the acute phase of myocardial infarction. After intravenous administration of IO or 20 mg, a negative chronotropic effect was observed which was associated with a moderate decrease in cardiac output but no change in stroke volume.
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Epois et al. (1972) studied this question.
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