Key result
Regional myocardial ischemia and 60 minutes of reperfusion were associated with persistent increases in chamber stiffness (+54%) and myocardial stiffness (+55%) in remote nonischemic myocardium (P<0.05).
Population
10 anesthetized (isoflurane 1.0% vol/vol) open-chest dogs
Comparison
45 min low flow ischemia followed by 60 min… vs Baseline measurements
Design
Preclinical
Follow-up
60 min after onset of reperfusion
Authors
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Should not change practice; leaves open whether remote myocardial stiffness increases translate to human ischemia-reperfusion injury.
Effect estimate: +54% chamber stiffness, +55% myocardial stiffness
p-value: p=<0.05
In a canine model, the ischemia-induced increase in stiffness of remote nonischemic myocardium persists for at least 60 minutes after reperfusion.
Märsch et al. (1996) studied Myocardial ischemia and reperfusion (n=10). Low flow ischemia and reperfusion vs. Baseline was evaluated on Chamber stiffness and myocardial stiffness in remote nonischemic myocardium (+54% chamber stiffness, +55% myocardial stiffness, p=<0.05). Regional myocardial ischemia and 60 minutes of reperfusion were associated with persistent increases in chamber stiffness (+54%) and myocardial stiffness (+55%) in remote nonischemic myocardium (P<0.05).
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