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March 1, 1994Cardiovascular Research

Effects of anaesthesia and recent surgery on diastolic function

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Why the study?

Does halothane anaesthesia and recent surgery affect left ventricular diastolic function in mongrel dogs?

Population

12 mongrel dogs

Comparison

Halothane anaesthesia (0.5-1.5 end tidal vol%) vs Conscious state

Design

Preclinical

Follow-up

2-3 weeks

Authors

TITadashi IharaSuzuka University of Medical ScienceRSRichard P. ShannonHeart Failure & TransplantKKKazuo KomamuraToyota Memorial Hospital

Discussion

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Implication

May confound diastolic assessment in anaesthetized canine models; leaves open translation to human perioperative echocardiography.

Structured PICO

Does halothane anaesthesia and recent surgery affect left ventricular diastolic function in mongrel dogs?

P
Population
12 mongrel dogs (8 studied after acute instrumentation and later conscious; 4 studied conscious and later under anaesthesia remote from instrumentation)
I
Intervention
Halothane anaesthesia (0.5-1.5 end tidal vol%)
C
Comparator
Conscious state
O
Outcome
Left ventricular isovolumetric relaxation time constant (tau), myocardial stiffness constant, and chamber stiffness constantsurrogate

Halothane anaesthesia combined with recent surgery significantly prolongs left ventricular isovolumetric relaxation time independently of loading conditions in a canine model.

Cite This Study

Ihara et al. (1994) studied this question.

synapsesocial.com/papers/6a853f02385dd211e7c2aaebhttps://doi.org/10.1093/cvr/28.3.325
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of halothane and isoflurane on left ventricular diastolic function during surgical stress in patients with coronary artery disease1997 · 22 citations
  2. 2Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade1991 · 93 citations
  3. 3Alterations of Normal Left Ventricular Performance by General Anesthesia1976 · 49 citations
  4. 4Effects of Halothane on Left Ventricular Relaxation and Early Diastolic Coronary Blood Flow in the Dog1989 · 30 citations
  5. 5Myocardial Function and Metabolism in the Conscious Dog and during Halothane Anesthesia1976 · 70 citations