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August 1, 1997Acta Anaesthesiologica Scandinavica

Effects of halothane and isoflurane on left ventricular diastolic function during surgical stress in patients with coronary artery disease

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Why the study?

Do halothane and isoflurane affect left ventricular diastolic function during surgical stress in patients with coronary artery disease?

Population

33 patients with coronary artery disease (CAD) undergoing sternotomy

Comparison

Halothane or isoflurane inhalation anesthesia… vs Baseline/control situation prior to surgery, and…

Design

Cohort

Follow-up

Intraoperative

Authors

EHErik HoultzSahlgrenska University HospitalKCKenneth CaidahlCardiac ImagingCAChristopher A. AdinUniversity of Florida

Discussion

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Implication

Warrants caution with volatiles in CAD patients under stress; leaves open clinical relevance and need for outcome trials.

Structured PICO

Do halothane and isoflurane affect left ventricular diastolic function during surgical stress in patients with coronary artery disease?

P
Population
33 patients with coronary artery disease (CAD) undergoing sternotomy
I
Intervention
Halothane or isoflurane inhalation anesthesia used to control the stress response to sternotomy
C
Comparator
Baseline/control situation prior to surgery, and comparison between the two anesthetics
O
Outcome
Left ventricular early diastolic relaxation and end-diastolic stiffness (evaluated from mitral Doppler flow profiles, transesophageal two-dimensional echocardiography, and central hemodynamic measurements)surrogate

Both halothane and isoflurane impair early diastolic relaxation during surgical stress in CAD patients, with isoflurane additionally increasing left ventricular end-diastolic stiffness.

Cite This Study

Houltz et al. (1997) studied this question.

synapsesocial.com/papers/6a6fa3d65d37378ac1dcb35bhttps://doi.org/10.1111/j.1399-6576.1997.tb04811.x

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Surgical Stress and Volatile Anesthetics on Left Ventricular Global and Regional Function in Patients With Coronary Artery Disease Evaluation by Computer-Assisted Two-Dimensional Quantitative Transesophageal Echocardiography1992 · 12 citations
  2. 2Alteration of Left Ventricular Diastolic Function by Desflurane, Isoflurane, and Halothane in the Chronically Instrumented Dog with Autonomie Nervous System Blockade1991 · 93 citations
  3. 3Echocardiographic evaluation and comparison of the effects of sevoflurane and desflurane on left ventricular relaxation indices in patients with diastolic dysfunction scheduled for coronary artery bypass grafting surgery2014 · 1 citations
  4. 4Desflurane and Isoflurane Exert Modest Beneficial Actions on Left Ventricular Diastolic Function during Myocardial Ischemia in Dogs1995 · 41 citations
  5. 5Isoflurane, but Not Halothane, Improves Indices of Diastolic Performance in Dogs with Rapid Ventricular, Pacing-induced Cardiomyopathy1996 · 30 citations