Why the study?
Does practolol reduce angina attacks and glyceryl trinitrate consumption in patients with angina pectoris?
Does practolol reduce angina attacks and glyceryl trinitrate consumption in patients with angina pectoris?
Practolol significantly reduces the frequency of angina attacks and the need for glyceryl trinitrate in patients with angina pectoris.
Supports practolol for angina symptom relief; confirms beta-blocker efficacy in this early RCT.
Twenty-four patients with angina pectoris entered a double-blind trial of the cardioselective beta-adrenergic blocking agent practolol. Seventeen experienced less angina and consumed fewer glyceryl trinitrate tablets when on the active preparation. There was also a decrease in the mean number of attacks suffered by patients while on practolol and a reduction in the number of glyceryl trinitrate tablets taken. These results are of statistical significance at, at least, the 5% level.
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George et al. (1970) studied this question.
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