Key result
Aging in beagle dogs prolonged cardiomyocyte action potential duration and delayed electrical repolarization, compromising contractile reserve under high hemodynamic demand.
Authors
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May caution against assuming preserved contractile reserve in elderly patients under stress; leaves open confirmation in human cardiomyocytes.
Observational
Sorrentino et al. (2016) conducted an observational in Myocardial aging. Aging vs. Young dogs was evaluated on Ventricular, myocardial, and myocyte function, and structural properties. Aging in beagle dogs prolonged cardiomyocyte action potential duration and delayed electrical repolarization, compromising contractile reserve under high hemodynamic demand.
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