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June 6, 2026Anaesthesia

Individualised vs. fixed positive end‐expiratory pressure: a reply

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Authors

WWW WangJWJianmin Wu

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Overview

Randomized trial investigates impact of individualized ventilation on postoperative outcomes, suggesting limited benefits.

Key Points

  • This research aims to determine patient-specific optimal positive end-expiratory pressure levels during surgery using impedance tomography.
  • Utilized electrical impedance tomography to assess individualized positive end-expiratory pressure levels during one- and two-lung ventilation.
  • Monitored and maintained individualized pressure settings throughout the surgical procedures.
  • Capturing the burden of postoperative pulmonary complications as primary outcomes.
  • No significant differences in postoperative complications related to ventilatory strategy, including atelectasis.
  • Improvements in intra-operative respiratory mechanics did not lead to clinically relevant reductions in complications.
  • High pressures during titration prompted the withdrawal of two patients, indicating potential risks associated with excessive positive end-expiratory pressure.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a23b96a71a5da9775e7566ahttps://doi.org/10.1111/anae.70257
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Individualised vs. fixed positive end‐expiratory pressure2026 · 1 citations
  2. 2One‐lung ventilation and positive end‐expiratory pressure titration: a reply2026
  3. 3The search for the missing link between better physiology and patient outcomes: a reply2026
  4. 4Interpreting individualised positive end‐expiratory pressure2026
  5. 5The search for the missing link between better physiology and patient outcomes2026 · 1 citations