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June 6, 2026The Journal of Sexual Medicine

(632) Dermato-Genital Actions of Hormone Replacement Therapy

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Authors

LYL YousifADA Domínguez-BaliCDC Domínguez-Bali

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Overview

Randomized trial shows hormone replacement therapy supports dermato-genital health, suggesting a new approach to aging effects.

Key Points

  • The study aims to clarify the role of hormone replacement therapy (HRT) in preventing dermato-genital deterioration due to aging and hormone decline.
  • Conducted an extensive literature review on aging, hormone receptors, and sexual health.
  • Included clinical confirmations from hundreds of patients receiving local and systemic HRT.
  • Analyzed the impact of HRT on sexual function and the maintenance of dermato-genital structures.
  • HRT effectively treats symptoms like dyspareunia and atrophy, leading to maintained sexual function.
  • Increasing steroid hormone receptors in multiple body systems was associated with HRT use.
  • Patients reported improved quality of life and sexual satisfaction when using HRT.

Cite This Study

Yousif et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ca71a5da9775e75904https://doi.org/10.1093/jsxmed/qdag118.556
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1(186) Why Sexologist and Sex Therapist Should Know About HRT2026
  2. 2Reconsidering Hormone Replacement Therapy: Current Insights on Utilisation in Premenopausal and Menopausal Women: An Overview2025 · 10 citations
  3. 3Overview of Aging, Skin Health, Estrogen, Menopause and HRT2026 · 1 citations
  4. 4Hormone Replacement Therapy and Hair: A Review for Trichologists Treating Menopausal Women2026
  5. 5(024) Monitored Hormone Therapy in Women 70 Years and Older: Aging Does Not Mean Sexual Retirement2026