What does this research mean for the field?

In real-world clinical practice, girls with Turner syndrome achieve greater unadjusted height-SDS gain from growth hormone therapy compared to those with SHOX deficiency, primarily due to later puberty and longer treatment duration, although both groups reach similar near-final height. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to compare growth response and near-final height after growth hormone therapy in girls with SHOX deficiency versus those with Turner syndrome.

June 6, 2026European Journal of PediatricsOpen Access

Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study

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Authors

MOMehmet Ali OktayGazi University EDEsra DöğerGazi University AUAylin Kılınç UğurluGazi Hastanesi

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Implication

Retrospective cohort study compares growth hormone therapy outcomes in SHOX deficiency and Turner syndrome, indicating key differences in growth response.

Key Points

This study aims to compare growth response and near-final height after growth hormone therapy in girls with SHOX deficiency versus those with Turner syndrome.
Single-centre retrospective cohort study reviewing 44 pre-pubertal girls receiving daily GH therapy.
Analysis of baseline auxology, annual height velocity, pubertal timing, and height-standard deviation scores.
Comparison of growth outcomes between girls with confirmed SHOX deficiency and those with Turner syndrome.
First-year growth velocity was significantly higher in SHOX (8.55 cm/year) than in TS (6.72 cm/year; p = 0.01).
Puberty began earlier in SHOX (11.6 years) than in TS (13.7 years; p < 0.01).
Observed near-final height-standard deviation scores were similar between groups, while unadjusted height-SDS gain was greater in TS (1.04) compared to SHOX (0.20; p = 0.04).

Cite This Study

Oktay et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9ca71a5da9775e759a4 https://doi.org/10.1007/s00431-026-07135-7

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Implication

Retrospective cohort study compares growth hormone therapy outcomes in SHOX deficiency and Turner syndrome, indicating key differences in growth response.

Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study

Discussion

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Implication

Key Points

Cite This Study

Growth hormone therapy and near-final height in SHOX deficiency and turner syndrome: a real-world single-center retrospective cohort study

Discussion

Member takes

Implication

Key Points

Cite This Study

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