What question did this study set out to answer?

To assess the long-term effectiveness and safety of growth hormone therapy in Japanese children diagnosed with growth hormone deficiency or Turner syndrome.

September 19, 2012Endocrine JournalOpen Access

An observational study of the effectiveness and safety of growth hormone (Humatrope®) treatment in Japanese children with growth hormone deficiency or Turner syndrome

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Authors

STShigeru TaiEli Lilly (Japan)TTToshiaki TanakaTanaka Holdings (Japan)THTomonobu HasegawaKeio University

Discussion

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Implication

Observational study demonstrates sustained height gains and low adverse event rates in children with growth hormone deficiency or Turner syndrome, indicating favorable long-term therapy profiles.

Key Points

To assess the long-term effectiveness and safety of growth hormone therapy in Japanese children diagnosed with growth hormone deficiency or Turner syndrome.
Multicenter, open-label observational study evaluating Japanese pediatric patients enrolled in the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) over up to 4 years.
Included 1,129 treatment-naïve children with growth hormone deficiency (mean age 8.75 ± 3.32 years) and 90 girls with Turner syndrome (mean age 8.93 ± 3.67 years) treated with Humatrope.
Mean height standard deviation score increased from -2.73 to -2.22 SD in the deficiency group and from -2.71 to -2.20 SD in the Turner syndrome group after 1 year, with continuing but diminishing annual gains through year 4.
Mean insulin-like growth factor-I standard deviation scores rose from baseline below-population averages to values comparable to or higher than the reference population throughout 4 years of treatment.
Serious adverse events, treatment-related adverse events, and glucose intolerance-related adverse events occurred at low incidences ranging between 0.1% and 3.0% across cohorts.

Cite This Study

Tai et al. (2012) studied this question.

synapsesocial.com/papers/6a9f84c5ee494a071104f035 https://doi.org/10.1507/endocrj.ej11-0386

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Implication

Observational study demonstrates sustained height gains and low adverse event rates in children with growth hormone deficiency or Turner syndrome, indicating favorable long-term therapy profiles.

An observational study of the effectiveness and safety of growth hormone (Humatrope®) treatment in Japanese children with growth hormone deficiency or Turner syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

An observational study of the effectiveness and safety of growth hormone (Humatrope®) treatment in Japanese children with growth hormone deficiency or Turner syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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