Key result
Growth hormone replacement therapy in Japanese adults with growth hormone deficiency was associated with a 36.1% incidence of adverse events and significant improvements in IGF-I standard deviation scores over 2 years.
Why the study?
Does growth hormone replacement therapy improve clinical, metabolic, and QoL characteristics and is it safe in Japanese adults with growth hormone deficiency?
Population
402 Japanese adults with growth hormone deficiency for safety analyses, and a subset of 209 patients who had…
Design
Cohort
Follow-up
2 years
Authors
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May support GH replacement in Japanese GHD adults; leaves open randomized confirmation of benefits and safety.
Observational (n=402)
Open-label
Yes
Does growth hormone replacement therapy improve clinical, metabolic, and QoL characteristics and is it safe in Japanese adults with growth hormone deficiency?
Growth hormone replacement therapy in Japanese adults with GHD improves IGF-I levels and quality of life in routine clinical practice, with a safety profile similar to the general population.
Shimatsu et al. (2013) conducted an observational in Growth hormone deficiency (GHD) (n=402). Growth hormone replacement therapy vs. None (single-arm study) was evaluated on Incidence of at least one adverse event. Growth hormone replacement therapy in Japanese adults with growth hormone deficiency was associated with a 36.1% incidence of adverse events and significant improvements in IGF-I standard deviation scores over 2 years.
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