Key result
The eNOS rs1799983 G allele presents at 73% frequency among Iraqi patients with essential hypertension.
Why the study?
Due to the polygenic character of hypertension, identifying single nucleotide polymorphisms linked with essential hypertension across various ethnic groups remains challenging.
Cross-Sectional (n=90)
No
In Iraqi patients with essential hypertension, the G allele for rs1799983 and T allele for rs2070744 are the most frequent eNOS gene polymorphisms.
Adds Iraqi-specific eNOS allele frequencies; extends ethnic variation data but leaves clinical or therapeutic relevance open.
Background: Due to the polygenic character of hypertension, it is particularly challenging to identify the single nucleotide polymorphisms most likely to be linked with essential hypertension and also the connections between certain genes and treatment responses in various ethnic groups. One of important genes is eNOS gene which encode eNOS enzyme that mediate NO production. Our study involve rs1799983 (G894T) and rs2070744 (T-786C) of eNOS gene. The objective of this observational cross-sectional descriptive study is to examine frequencies of allele of eNOS3 genes. Methods: ninety hypertensive patients were recruited by specialist cardiologist and conducted at AL-Diwaniyah teaching hospital and department of pharmacology and therapeutics, college of medicine, University of Al-Qadisiyah, Iraq. DNA samples were genotyped by PCR-tetra-arm method. Results: Regarding rs1799983 the most frequent allele was G (73%) and the most frequent genotype was GG (55%), while rs2070744 the most frequent allele was T (66%) and the patients had higher frequency of TT + TC genotypes 43%, 47% respectively. Conclusion: This study concluded the most common allele for rs1799983 was G allele (73%). Regarding rs2070744 the most frequent allele was T (66%).
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Salman et al. (2026) conducted a cross-sectional in essential hypertension (n=90). eNOS gene polymorphisms (rs1799983 and rs2070744) was evaluated on frequencies of allele of eNOS3 genes. In Iraqi patients with essential hypertension, the most frequent eNOS gene alleles were G (73%) for rs1799983 and T (66%) for rs2070744.
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