Key result
eNOS rs1799983 polymorphism shows no association with nitric oxide or blood pressure in essential hypertension.
Why the study?
To investigate allele frequencies of the rs1799983 polymorphism in eNOS genes and determine its association with essential hypertension in Iraqi hypertensive patients.
Does the rs1799983 polymorphism of the eNOS gene affect NO levels and blood pressure in Iraqi patients with essential hypertension?
Cross-Sectional (n=90)
No
Does the rs1799983 polymorphism of the eNOS gene affect NO levels and blood pressure in Iraqi patients with essential hypertension?
p-value: p=0.88
The rs1799983 polymorphism of the eNOS gene is not significantly associated with NO levels or blood pressure severity in Iraqi patients with essential hypertension.
Rs1799983 shows no link to NO or BP in Iraqi hypertensives; leaves open ethnic variation in genetic associations.
OBJECTIVE: Aim: To investigate allele frequencies of rs1799983 polymorphism eNOS genes and to determine association between rs1799983 polymorphism of eNOS gene and essential hypertension in Iraqi hypertensive patients. PATIENTS AND METHODS: Materials and Methods: This is an observational cross sectional descriptive single center study. ninety hypertensive patients were recruited by specialist cardiologist and conducted at AL-Diwaniyah teaching hospital and department of pharmacology and therapeutics, college of medicine, university of Al-Qadisiyah, Iraq. DNA samples were genotyped by PCR-tetra-arm method. NO level was measured by using ELISA kit. RESULTS: Results: Regarding rs1799983 the most frequent allele was G (73%) and the most frequent genotype was GG (55%). Our results indicate lack of substantial link between genotype frequencies of rs1799983 polymorphism and NO level (p=0.88) and thereby there is no statistically significant effect on SBP and DBP (p = 0.051). CONCLUSION: Conclusions: our study demonstrated lack of significant association between this polymorphism and essential hypertension in Iraqi hypertensive patients.
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Salman et al. (2024) conducted a cross-sectional in essential hypertension (n=90). eNOS rs1799983 polymorphism vs. Different genotypes (GG, GT, TT) was evaluated on Association between genotype frequencies and nitric oxide (NO) level (p=0.88). The eNOS rs1799983 polymorphism showed no significant association with nitric oxide levels (p=0.88) or blood pressure (p=0.051) in Iraqi patients with essential hypertension.
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