Key result
Significant variations in the management of acute coronary syndromes were observed between two neighboring Swiss university hospitals, such as sublingual nitroglycerin use (9% vs 56%; p<0.0001).
Why the study?
Variations in practice patterns for common medical conditions have been reported in several countries, but this phenomenon has been little documented in Switzerland.
Are there significant geographic variations in the management of acute coronary syndromes between two neighboring university hospitals?
Observational (n=1,433)
Yes
Are there significant geographic variations in the management of acute coronary syndromes between two neighboring university hospitals?
Answers are grounded in this paper and cite their sources.
Significant variations in the medical management of acute coronary syndromes exist even between neighboring university hospitals, highlighting the need for standardized adherence to evidence-based recommendations.
Geographic Variations in practice patterns for patients with acute coronary syndromes. Variations in practice patterns for common medical conditions have been reported in several countries. This phenomenon has been little documented in Switzerland. Thus, we included in an observational study 1433 consecutive patients with acute coronary syndrome, admitted from 01.07.1994 to 30.06.1996 to two university hospitals of the French speaking part of Switzerland. In spite of rather similar clinical characteristics, more patients received sublingual nitroglycerin upon admission in hospital B (56% versus 9%; p<0.0001) as well as aspirin (71% versus 65%; p<0.02), while more patients got beta-blockers in hospital A (28% versus 13%; p<0.0001). Similar rates of reperfusion therapy for AMI (thrombolysis or primary angioplasty) were observed in the two hospitals. Admission rates to intensive care units were similar in the two hospitals and for both diagnoses; however, more patients were admitted to non-monitored beds in hospital A (21% versus 1%; p0.0001) and calcium antagonists (42% versus 19%; p<0.0001), while more such patients got p.o. nitrates at hospital A (62% versus 44%; p<0.0001). Similar trends were observed for AMI patients, who were prescribed more betablockers at discharge from hospital B (59% versus 50%; p<0.03). Thus, important variations have been observed in the management of UA and AMI patients at two Swiss university hospitals, distant from only 60 km. These local patterns of care need to be further investigated and confronted with evidence based recommendations. Des variations de pratique pour des soins courants ont été constatées dans différents pays. Ce phénomène est peu documenté en Suisse. Ainsi, la prise en charge de 1433 patients, avec syndrome coronarien aigu, admis de 1994 à 1996 dans deux hôpitaux universitaires de Suisse romande, a été analysée. A l’admission, moins de patients reçurent de la nitroglycérine sublinguale (9% versus 56%; p<0,0001) ainsi que de l’aspirine (71% versus 65%; p<0,02) à l’hôpital A qu’à l’hôpital B, alors que plus de patients reçurent des bêtabloqueurs (28% versus 13%; p<0,0001). Le taux d’angioplastie primaire, de thrombolyse et d’admissions en soins intensifs fut identique dans les deux hôpitaux; toutefois, plus de patients furent admis en unité non-monitorée à l’hôpital A (21% versus 1%; p<0,0001). Un diagnostic final d’infarctus aigu du myocarde fut posé chez une proportion similaire de patients (55%) dans les deux centres et les durées de séjour ainsi que la mortalité hospitalière furent équivalentes. A la sortie, plus de patients avec angor instable reçurent des anticalciques (42% versus 19%; p<0,0001) à l’hôpital B, et à l’hôpital A, des dérivés nitrés retard (62% versus 44%; p<0,0001). Chez les patients avec infarctus, des bêtabloqueurs furent plus souvent prescrits à l’hôpital B (59% versus 50%; p<0,03). Ainsi, des variations importantes ont été relevées dans la prise en charge des patients avec syndrome coronarien aigu entre deux hôpitaux universitaires suisses distants d’à peine 60 km.
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Gaspoz et al. (2000) conducted an observational in Acute coronary syndrome (n=1,433). Admission to Hospital A vs. Admission to Hospital B was evaluated on Sublingual nitroglycerin upon admission (p=<0.0001). Significant variations in the management of acute coronary syndromes were observed between two neighboring Swiss university hospitals, such as sublingual nitroglycerin use (9% vs 56%; p<0.0001).
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