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June 6, 2026

Predictive Factors for Successful Discontinuation of Continuous Renal Replacement Therapy: A Retrospective Single-Center Observational Study.

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Authors

MEMete ErdemirÖGÖzlem GürbüzHSHakan Sapmaz

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Overview

Retrospective analysis identifies key clinical factors linked to successful CRRT discontinuation in critically ill patients, indicating the importance of urine output and lactate trends.

Key Points

  • This study aims to identify factors predicting successful discontinuation of continuous renal replacement therapy in patients with acute kidney injury.
  • Retrospective analysis of 396 patients receiving CRRT, excluding 316 with prior RRT or end-stage kidney disease, resulting in 80 patients analyzed.
  • Successful discontinuation defined as no renal replacement therapy for at least seven days.
  • Clinical variables compared between successful and unsuccessful CRRT discontinuation groups.
  • Successful discontinuation correlated with higher 24-h urine output (385 mL vs. 100 mL; P=0.010) and stable lactate trends (69% vs. 40%; P=0.033).
  • ROC analysis showed urine output as a predictor (AUC=0.666; P=0.011) with a sensitivity of 52.3% and specificity of 80.6% for success at 365 cc/24h.
  • Logistic regression confirmed urine output as an independent predictor of weaning success (OR=1.001; P=0.009).

Cite This Study

Erdemir et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76cfdhttps://doi.org/10.61882/ijkd.3.03.8885
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Factors associated with successful transition from continuous renal replacement therapy in critically ill patients: a retrospective cohort study2025 · 3 citations
  2. 2Validation of prediction model for successful discontinuation of continuous renal replacement therapy: a multicenter cohort study2024 · 2 citations
  3. 3Discontinuation of continuous kidney replacement therapy in patients with acute kidney injury: A pilot study2026 · 2 citations
  4. 4Factors Influencing Unplanned Discontinuation of Continuous Renal Replacement Therapy: A Descriptive Time‐Series Analysis2026
  5. 5Predictive factors of successful renal replacement therapy weaning2026 · 3 citations