What question did this study set out to answer?

To evaluate the risk factors and temporal patterns associated with unplanned continuous renal replacement therapy (CRRT) discontinuation in critically ill patients to guide nursing interventions.

August 14, 2026Nursing in Critical Care

Factors Influencing Unplanned Discontinuation of Continuous Renal Replacement Therapy: A Descriptive Time‐Series Analysis

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Authors

WJWanning JiaChina-Japan Friendship Hospital HXHongjiao XuShanghai Medical College of Fudan University RPRuihan PengSichuan University

Discussion

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Overview

Retrospective cohort study identifies predictors of unplanned continuous renal replacement therapy discontinuation in critically ill patients, highlighting the role of anticoagulation protocols.

Key Points

To evaluate the risk factors and temporal patterns associated with unplanned continuous renal replacement therapy (CRRT) discontinuation in critically ill patients to guide nursing interventions.
Retrospective cohort study of 3128 CRRT sessions conducted at a tertiary hospital in China between January and December 2025.
Univariate analysis and binary logistic regression were used to identify independent predictors of unplanned discontinuation.
Descriptive time-series analysis with 7-day moving average smoothing evaluated temporal variations across the study period.
Unplanned discontinuation occurred in 77 of 3128 CRRT sessions (2.46%), with elevated circuit pressure serving as the leading cause.
Treatment duration (p < 0.001) and net ultrafiltration rate (p = 0.032) were independent predictors of unplanned treatment discontinuation.
Compared with no anticoagulation, nafamostat mesylate was associated with lower odds of unplanned discontinuation (p = 0.013), whereas sodium citrate was associated with higher odds (p = 0.004).

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a7ee587b70b84ec8b91472d https://doi.org/10.1111/nicc.70637

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August 14, 2026Nursing in Critical Care

Factors Influencing Unplanned Discontinuation of Continuous Renal Replacement Therapy: A Descriptive Time‐Series Analysis

View Full Paper

Ask AI

Bookmark

Authors

WJWanning JiaChina-Japan Friendship Hospital HXHongjiao XuShanghai Medical College of Fudan University RPRuihan PengSichuan University

Discussion

Member takes

Overview

Retrospective cohort study identifies predictors of unplanned continuous renal replacement therapy discontinuation in critically ill patients, highlighting the role of anticoagulation protocols.

Key Points

To evaluate the risk factors and temporal patterns associated with unplanned continuous renal replacement therapy (CRRT) discontinuation in critically ill patients to guide nursing interventions.
Retrospective cohort study of 3128 CRRT sessions conducted at a tertiary hospital in China between January and December 2025.
Univariate analysis and binary logistic regression were used to identify independent predictors of unplanned discontinuation.
Descriptive time-series analysis with 7-day moving average smoothing evaluated temporal variations across the study period.
Unplanned discontinuation occurred in 77 of 3128 CRRT sessions (2.46%), with elevated circuit pressure serving as the leading cause.
Treatment duration (p < 0.001) and net ultrafiltration rate (p = 0.032) were independent predictors of unplanned treatment discontinuation.
Compared with no anticoagulation, nafamostat mesylate was associated with lower odds of unplanned discontinuation (p = 0.013), whereas sodium citrate was associated with higher odds (p = 0.004).

Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6a7ee587b70b84ec8b91472d https://doi.org/10.1111/nicc.70637

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