Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes

Rambabu Kandukuri; Madhu Inapanuri; Nagaraju Naddi; Hari Prasad Kokatla

doi:10.1039/d6ob00637j

January 1, 2026Organic & Biomolecular Chemistry

Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes

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Key Points

This research aims to develop a method for geminal difunctionalization of fluorene derivatives without using transition metals.
Transition-metal-free strategy utilizing rongalite for functionalization.
Focused on the synthesis of (9-methyl-9H-fluoren-9-yl)methanol derivatives.
Evaluated efficiency of the transformation process.
Successfully synthesized various (9-methyl-9H-fluoren-9-yl)methanol derivatives.
Demonstrated increased efficiency in the chemical transformations compared to traditional methods.

Implication

Demonstrates geminal difunctionalization in fluorene derivatives, highlighting metal-free synthesis efficiency.

Abstract

A transition-metal-free rongalite-mediated strategy has been developed for the geminal difunctionalization of fluorene derivatives, enabling the efficient synthesis of (9-methyl-9H-fluoren-9-yl)methanols derivatives. In this transformation, rongalite plays a dual role as...

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Cite This Study

Kandukuri et al. (2026) studied this question.

synapsesocial.com/papers/6a23bc0571a5da9775e77608 https://doi.org/10.1039/d6ob00637j

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Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Transition Metal-Free Rongalite-Mediated Geminal C(sp³)–H Functionalization of Fluorenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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