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June 6, 2026Hormones and BehaviorOpen Access

Supraphysiological androgen administration does not exert any additive benefits on hippocampal plasticity-related markers and behavior in previously untrained male mice

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Authors

TBTavor Ben‐ZeevCLChagai LeviNRNicholas A. Ratamess

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Overview

Randomized trial investigates resistance training and supraphysiological nandrolone effects on neurogenesis and behavior in male mice, suggesting limited additive benefits.

Key Points

  • The study aims to evaluate how resistance training and supraphysiological nandrolone decanoate impact hippocampal plasticity and behavior in male mice.
  • Forty male C57BL/6 J mice were randomized to resistance training or sedentary conditions for 7 weeks.
  • Mice were further divided into sham or nandrolone (38 mg·kg −1 ·wk. −1 ) treatment groups.
  • Hippocampal neurogenesis was quantified using BrdU + /NeuN + immunolabeling and molecular markers assessed by western blot analyses.
  • Resistance training increased the number of BrdU + /NeuN + cells (p = 0.001) and elevated open-arm entries (p = 0.006) compared to sedentary.
  • Nandrolone administration also increased BrdU + /NeuN + cell numbers (p = 0.032) but did not enhance behavioral outcomes.
  • Resistance training and nandrolone both increased expression of AR, ER-β, and BDNF without additive effects.

Cite This Study

Ben‐Zeev et al. (2026) studied this question.

synapsesocial.com/papers/6a23bc5171a5da9775e77a34https://doi.org/10.1016/j.yhbeh.2026.105948
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Also Consider

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  1. 1Aerobic and Resistance Exercise Modalities Ameliorate Hippocampal Plasticity and Neurocognitive Changes Induced by Receiving Nandrolone Decanoate in Rats (Physiological, Biochemical, and Histological Study)2026
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  4. 4Alterations in hippocampal calcineurin protein levels are associated with the impairing effects of nandrolone on dorsal and ventral hippocampus-dependent memory in rats2026
  5. 5Restoration of hippocampal adult neurogenesis by CDRI‐08 (<scp><i>Bacopa monnieri</i></scp> extract) relates with the recovery of BDNF–TrkB levels in male rats with moderate grade hepatic encephalopathy2024 · 1 citations