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August 19, 2026Behavioral and Brain FunctionsOpen Access

Alterations in hippocampal calcineurin protein levels are associated with the impairing effects of nandrolone on dorsal and ventral hippocampus-dependent memory in rats

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Authors

RSRomina SalmaniSASamad AlimohammadiFZFatemeh Zarei

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Overview

Preclinical study reveals nandrolone increases hippocampal calcineurin and impairs spatial memory in rats, suggesting a molecular basis for anabolic steroid neurotoxicity.

Key Points

  • To determine whether nandrolone decanoate-induced learning and memory impairments are associated with alterations in calcineurin protein expression in the dorsal and ventral hippocampus.
  • Randomized 27 male rats into three groups (n=9 per group) receiving intraperitoneal injections of nandrolone decanoate (5 or 15 mg/kg) or sesame oil vehicle every third day for 22 days.
  • Assessed spatial learning, aversive memory, and anxiety-like behavior using the Morris water maze, passive avoidance test, and open field test.
  • Dissected dorsal and ventral hippocampal subregions post-behavioral testing and quantified calcineurin protein levels via enzyme-linked immunosorbent assay (ELISA).
  • Nandrolone decanoate administration significantly impaired spatial learning and memory in the Morris water maze and avoidance memory in the passive avoidance test.
  • Calcineurin protein concentrations were significantly elevated in both the dorsal and ventral hippocampus of nandrolone-treated rats.
  • Nandrolone exposure reduced anxiety-like behavior in the open field test without significantly modifying total locomotor activity.

Cite This Study

Salmani et al. (2026) studied this question.

synapsesocial.com/papers/6a85630603308d306e2d5fd8https://doi.org/10.1186/s12993-026-00363-9
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