Key result
Angiotensin II and endothelin-1 exerted similar mitogenic effects and increased intracellular free Ca2+ in vascular smooth muscle cells from both young spontaneously hypertensive and normotensive rats.
Population
Primary cultures of vascular smooth muscle cells from aortas of young spontaneously hypertensive rats and…
Comparison
Incubation with Angiotensin II or endothelin-1… vs Unstimulated cells and comparison between SHR…
Design
Preclinical
Follow-up
48 hours (culture duration)
Authors
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No pre-hypertensive VSMC differences evident in SHR; leaves open PKC pathway divergence in disease models.
Inborn differences in VSMC proliferation between SHR and WKY rats are not apparent in response to Ang-II and ET-1 before hypertension onset, though PKC signaling pathways may differ.
Boaz D. Rosen (1999) studied Hypertension. Angiotensin II and Endothelin-1 vs. Wistar-Kyoto rats (normotensive control) / baseline was evaluated on Thymidine incorporation into DNA (DNA synthesis) and intracellular free Ca2+. Angiotensin II and endothelin-1 exerted similar mitogenic effects and increased intracellular free Ca2+ in vascular smooth muscle cells from both young spontaneously hypertensive and normotensive rats.
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