Why the study?
Does an Angiotensin II type 1 receptor antagonist regulate the cell cycle in vascular smooth muscle cells from spontaneously hypertensive rats?
Does an Angiotensin II type 1 receptor antagonist regulate the cell cycle in vascular smooth muscle cells from spontaneously hypertensive rats?
Endogenous Angiotensin II enhances cell cycle progression from G1 to S phase in vascular smooth muscle cells of spontaneously hypertensive rats, which can be inhibited by an AT1 receptor antagonist.
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AT1 antagonism may selectively modulate VSMC cell cycle in hypertensive models; leaves open translation to human vascular remodeling.
Kubo et al. (2000) studied this question.
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