Population
Homogeneous cultures of vascular smooth muscle cells derived from spontaneously hypertensive rats and…
Comparison
Pharmacological probes including CV-11974… vs VSMC from normotensive Wistar-Kyoto rats…
Design
Preclinical
Authors
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Hypothesis-generating for local Ang II production in hypertensive VSMCs; leaves open human relevance and therapeutic targeting.
Vascular smooth muscle cells from spontaneously hypertensive rats autonomously produce Angiotensin II, suggesting a local cellular mechanism contributing to hypertensive vascular disease.
Fukuda et al. (1999) studied this question.
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