April 24, 1990FEBS LettersOpen Access

Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

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Population

Cultured bovine endothelial cells

Design

Preclinical

Authors

TEToshiaki EmoriFuchu Hospital YHYukio HirataCross-Cutting Cardiology FMFumiaki MarumoTokyo Institute of Technology

Discussion

Member takes

Implication

Elucidates ET-3 endothelial signaling; leaves open translation to human vascular function.

Structured PICO

Population

Cultured bovine endothelial cells

Intervention

Endothelin-3 (ET-3) at doses of 10(-10)-10(-7) M

Outcome

Intracellular Ca2+ levels ([Ca2+]i) and inositol trisphosphate (IP3) formationsurrogate

ET-3 induces phosphoinositide breakdown and intracellular Ca2+ mobilization in endothelial cells, providing a cellular mechanism for its vasodilatory action.

Cite This Study

Emori et al. (1990) studied this question.

synapsesocial.com/papers/6a23bd859e1c90a91c092c06 https://doi.org/10.1016/0014-5793(90)81388-5

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Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specific receptors for endothelin‐3 in cultured bovine endothelial cells and its cellular mechanism of action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider