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June 6, 2026BMC MedicineOpen Access

A large-scale single-nucleus resource reveals a cardiomyocyte-like fibroblast and stage-specific remodeling across cardiomyopathies

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Key result

Single-nucleus transcriptomics of 525 cardiac samples reveals distinct stage-specific remodeling trajectories in HCM and DCM.

  • n=525

Why the study?

Cardiomyopathies are a heterogeneous group of myocardial disorders, but their cell-type-specific mechanisms and differences remain incompletely defined.

Population

525 cardiac tissue samples spanning DCM, HCM, ARVC, LVNC, and non-failing controls

Comparison

DCM, HCM, ARVC, and LVNC vs non-failing controls

Design

Single-nucleus transcriptomic atlas

Authors

QTQianzi TangXLXingyu LiXFXiongwei Fan

Discussion

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Overview

May guide phenotype-specific cardiomyopathy therapies; leaves open translation from animal models to human practice.

Key Points

  • The study aims to define cell-type-specific mechanisms and differences in cardiomyopathies through a comprehensive transcriptomic atlas.
  • Analyzed 525 cardiac tissue samples, integrating over 2 million single nuclei from various cardiomyopathy types and controls.
  • Identified distinct fibroblast subpopulations and their remodeling roles in dilated and hypertrophic cardiomyopathies.
  • Mapped dynamic changes in cellular signaling at different disease stages.
  • Identified a fibroblast subpopulation expressing cardiomyopathy genes, with reparative potential in specific states.
  • HCM showed compensatory hypertrophic remodeling, while DCM exhibited cardiomyocyte loss and maladaptive fibroblast expansion.
  • LVEF-associated pseudotime staging highlighted dynamic remodeling processes differing between early HCM and DCM.

Study Design

Type

Observational (n=525)

Structured PICO

P
Population
525 cardiac tissue samples spanning dilated, hypertrophic, arrhythmogenic right ventricular, and left ventricular non-compaction cardiomyopathies, alongside non-failing controls.
E
Exposure
Single-nucleus transcriptomic profiling and integration (Cardiac Cell Atlas)
C
Comparator
Non-failing controls
O
Outcome
Cell-type-specific mechanisms, shared remodeling signatures, and divergent trajectories across cardiomyopathiessurrogate

A large-scale single-nucleus transcriptomic atlas of human cardiomyopathies reveals a novel cardiomyocyte-like fibroblast subpopulation and distinct stage-specific remodeling trajectories in HCM and DCM.

Cite This Study

Tang et al. (2026) conducted an observational in Cardiomyopathies (n=525). Cardiomyopathy vs. Non-failing controls was evaluated on Cell-type-specific mechanisms and remodeling trajectories. Single-nucleus transcriptomic profiling of 525 cardiac samples identified a cardiomyocyte-like fibroblast subpopulation and revealed distinct stage-specific remodeling trajectories in HCM and DCM.

synapsesocial.com/papers/6a23bf1671a5da9775e77cd4https://doi.org/10.1186/s12916-026-04954-1
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