Key result
Integrin alpha2beta1 activation by ADP involves differential contributions by P2Y1 and P2Y12 receptors, with a stronger contribution from P2Y12, and is independent of intracellular calcium release.
Population
Platelet preparations
Design
Preclinical
Authors
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Does not support changes to antiplatelet therapy; leaves open P2Y12-dominant integrin signaling in human platelets.
Integrin alpha2beta1 activation by ADP involves differential contributions by P2Y1 and P2Y12 receptors, with P2Y12 having a stronger role, and occurs independently of intracellular calcium release.
Jung et al. (2001) studied Platelet activation. P2Y12 and P2Y1 antagonists was evaluated on Integrin alpha2beta1 activation. Integrin alpha2beta1 activation by ADP involves differential contributions by P2Y1 and P2Y12 receptors, with a stronger contribution from P2Y12, and is independent of intracellular calcium release.
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