January 1, 2002BloodOpen Access

Adenosine diphosphate (ADP)–induced thromboxane A2generation in human platelets requires coordinated signaling through integrin αIIbβ3 and ADP receptors

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Population

Human platelets

Design

Preclinical

Authors

JJJianguo JinHangzhou First People's Hospital TQTodd M. QuintonTemple University JZJin ZhangZhejiang Sci-Tech University

Discussion

Member takes

Implication

May guide dual-receptor targeting strategies; leaves open translation to human platelet function and antithrombotic therapy.

Structured PICO

Population

Human platelets

Intervention

P2Y12 receptor antagonist (AR-C67085), P2Y1 receptor antagonist (A2P5P), fibrinogen receptor antagonist (SC49992), and LIBS6 antibody

Outcome

ADP-induced thromboxane A2 generation and arachidonic acid liberationsurrogate

ADP-induced thromboxane A2 generation in human platelets requires coordinated signaling through both P2Y receptors and the fibrinogen receptor (integrin αIIbβ3).

Cite This Study

Jin et al. (2002) studied this question.

synapsesocial.com/papers/6a700463ac440176ef28ac2a https://doi.org/10.1182/blood.v99.1.193

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Adenosine diphosphate (ADP)–induced thromboxane A2generation in human platelets requires coordinated signaling through integrin αIIbβ3 and ADP receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adenosine diphosphate (ADP)–induced thromboxane A2generation in human platelets requires coordinated signaling through integrin αIIbβ3 and ADP receptors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider