Key result
Recommended physical activity linked to better cardiac autonomic regulation in breast cancer survivors.
Why the study?
Cardiac autonomic regulation is a less recognized contributor to cardiometabolic risk in breast cancer survivors that may play a complementary role in behaviors associated with better prognosis, such as physical training.
Does meeting physical activity recommendations improve cardiac autonomic regulation, metabolic, and psychological profiles in breast cancer survivors?
Observational (n=172)
Does meeting physical activity recommendations improve cardiac autonomic regulation, metabolic, and psychological profiles in breast cancer survivors?
p-value: p=0.005
Meeting physical activity recommendations is associated with improved cardiac autonomic regulation, metabolic, and psychological profiles in breast cancer survivors, potentially mitigating their increased cardiometabolic risk.
May inform activity counseling in breast cancer survivors; leaves open causality and prospective cardiometabolic impact.
The increased cardiometabolic risk observed in breast cancer survivors (BCS) is due to multiple mechanisms: Hormonal and immunological dysfunction are well-identified ones, while cardiac autonomic regulation (CAR) is less recognized but may play a new complementary role particularly relevant when considering conditions and behaviors associated with a better prognosis in BCS, such as physical training. This observational study investigated a group of consecutive (172) BCS subdivided in two groups: those who reached the physical activity goals above 600 (MET·min/week) and those who did not. We assessed CAR by autoregressive spectral analysis of cardiovascular variabilities (considering in particular the unitary autonomic nervous system index-ANSI), body mass composition, stress perception and lifestyle in order to verify possible differences due to execution of physical activity. Subjects who spontaneously met physical activity recommendations presented a better autonomic, metabolic and psychological profile compared to those who did not. Lower physical activity volume, poor metabolic parameters, increased stress and fatigue perception may cluster together, leading to worsened CAR. This control mechanism may play a complementary role in determining the increased cardiometabolic risk observed in BCS. Furthermore, it may also explain, albeit in part, the better prognosis observed in patients following interventions aiming to improve the sympathetic-parasympathetic balance, such as physical training, using a personalized medicine approach.
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Lucini et al. (2022) conducted an observational in Breast cancer survivors (n=172). Meeting current physical activity recommendations (≥600 MET·min/week) vs. Not meeting current physical activity recommendations (<600 MET·min/week) was evaluated on Cardiac autonomic regulation (CAR) assessed by unitary autonomic nervous system index (ANSI) (p=0.005). Breast cancer survivors who spontaneously met physical activity recommendations (≥600 MET·min/week) exhibited significantly better cardiac autonomic regulation (higher ANSI, p=0.005).
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