Why the study?
Does antiarrhythmic drug therapy guided by programmed electrical stimulation prevent sudden death or VT recurrence in patients with idiopathic dilated cardiomyopathy and sustained VT?
Does antiarrhythmic drug therapy guided by programmed electrical stimulation prevent sudden death or VT recurrence in patients with idiopathic dilated cardiomyopathy and sustained VT?
In patients with idiopathic dilated cardiomyopathy and sustained VT, antiarrhythmic drugs (including amiodarone) often fail to suppress VT inducibility, and sudden death can still occur, highlighting the need for more aggressive therapies like ICD implantation.
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May indicate limited efficacy of PES-guided drugs against sudden death when VT remains inducible; leaves open optimal therapy in idiopathic dilated cardiomyopathy.
Poll et al. (1984) studied this question.