Key result
Induction of ventricular tachycardia or fibrillation during programmed ventricular stimulation was associated with a higher rate of future ICD activation (HR 4.195; 95% CI 1.467-11.994; P=0.007).
Why the study?
Does inducibility of ventricular tachycardia/ventricular fibrillation during programmed ventricular stimulation predict overall mortality and appropriate ICD activation in patients with idiopathic dilated cardiomyopathy?
Population
158 patients with idiopathic dilated cardiomyopathy
Comparison
Programmed ventricular stimulation with… vs Programmed ventricular stimulation without…
Design
Cohort
Follow-up
mean 46.9 months
Authors
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May inform sudden death risk stratification in idiopathic dilated cardiomyopathy; leaves open whether programmed stimulation should guide ICD decisions.
Cohort (n=158)
Does inducibility of ventricular tachycardia/ventricular fibrillation during programmed ventricular stimulation predict overall mortality and appropriate ICD activation in patients with idiopathic dilated cardiomyopathy?
Hazard Ratio: 4.195 (95% CI 1.467–11.994)
Absolute Event Rate: 73.2% vs 17.9%
p-value: p=0.007
Inducibility of ventricular tachycardia or ventricular fibrillation during programmed ventricular stimulation in patients with idiopathic dilated cardiomyopathy is a strong independent predictor of subsequent appropriate ICD activation.
Gatzoulis et al. (2013) conducted a cohort in idiopathic dilated cardiomyopathy (n=158). Induction of ventricular tachycardia/ventricular fibrillation vs. No induction of ventricular tachycardia/ventricular fibrillation was evaluated on Appropriate ICD activation among ICD recipients (HR 4.195, 95% CI 1.467-11.994, p=0.007). Induction of ventricular tachycardia or fibrillation during programmed ventricular stimulation was associated with a higher rate of future ICD activation (HR 4.195; 95% CI 1.467-11.994; P=0.007).
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