Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Figures

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  Figure 1. Current understanding of the renin-angiotensin system 2021. Black font indicates the classical RAS circa 1990. Red font indicates additional metabolic and signaling pathways that have been incorporated into the RAS since 1990. Proteins, enzymes, and receptors indicated in gray boxes are the proteins whose genes were evaluated in this analysis. Dotted lines indicate hypothetical pathways. ??Uncharacterized enzymatic mediators.

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  Figure 2. RAS components that showed highly significant differences in gene expression between normal and tumor tissues. (a, b) Describe angiotensinogen gene (AGT) expression, (c, d) describe renin gene (REN) expression, and (e, f) describe Mas receptor gene (MAS1) expression. (a, c, and e) Show pairing of samples with connecting lines. (b, d, and f) Show mean, SEM, and individual data points. All of these comparisons were significant at the p < 0.01 level after correction for multiple comparisons.

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  Figure 3. RAS-related enzymes that showed highly significant differences in gene expression between normal and tumor tissues. (a–j) Describe neprilysin gene (MME) expression, thimet oligopeptidase gene (THOP) expression, neurolysin gene (NLN) expression, prolyl endopeptidase gene (PREP) expression, and aminopeptidase N gene (ANPEP) expression. (a, c, e, g, and i) Show pairing of samples with connecting lines. (b, d, f, h, and j) Show mean, SEM, and individual data points. All of these comparisons were significant at the p < 0.01 level after correction for multiple comparisons.

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  Figure 4. RAS-related components that showed significant (p < 0.05) differences in gene expression between normal and tumor tissues. (a, b) Describe prorenin receptor gene (ATP6AP2) expression, and (c, d) describe aminopeptidase A gene (ENPEP) expression. (a, c) Show pairing of samples with connecting lines. (b, d) Show mean, SEM, and individual data points. All of these comparisons wesssre significant at the p < 0.05 level after correction for multiple comparisons.