March 1, 1968The Journal of Experimental MedicineOpen Access

Pathogenesis of the Glomerulonephritis of NZB/W Mice

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Population

NZB/W mice

Design

Preclinical

Authors

PLPaul‐Henri LambertUniversity of Geneva FDFrank J. DixonUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Establishes anti-DNA pathogenicity in murine lupus nephritis models; leaves open translation to human disease and therapies.

Structured PICO

Population

NZB/W mice

Intervention

Active immunization with DNA-methylated BSA or injections of soluble DNA

Outcome

Development and severity of glomerulonephritissurrogate

The study demonstrates that antinuclear antibodies, particularly anti-DNA antibodies, play a direct pathogenic role in the development of glomerulonephritis in NZB/W mice.

Cite This Study

Lambert et al. (1968) studied this question.

synapsesocial.com/papers/6a23dae69e1c90a91c095685 https://doi.org/10.1084/jem.127.3.507

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Pathogenesis of the Glomerulonephritis of NZB/W Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Pathogenesis of the Glomerulonephritis of NZB/W Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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