The Effect of Induced Chronic Viral Infections on the Immunologic Diseases of New Zealand Mice
Why the study?
Does induced chronic viral infection increase mortality and autoimmune disease severity in New Zealand mice?
Population
NZB, NZW, and NZB x W mice
Comparison
Chronic infections induced at birth with either… vs Uninfected controls
Design
Preclinical
Follow-up
up to 9 months
Authors
Discussion
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Member takes
Implication
Suggests chronic viruses may aggravate autoimmune glomerulonephritis in mice; leaves open relevance to human disease.
Structured PICO
Does induced chronic viral infection increase mortality and autoimmune disease severity in New Zealand mice?
P
Population
NZB, NZW, and NZB x W mice
I
Intervention
Chronic infections induced at birth with either LCM (an RNA virus) or polyoma (a DNA virus)
C
Comparator
Uninfected controls
O
Outcome
ANA formation, immune complex glomerulonephritis severity, and associated mortalityhard clinical
Chronic viral infections induced at birth in New Zealand mice aggravate immune complex glomerulonephritis and significantly increase mortality.
Cite This Study
Tonietti et al. (1970) studied this question.