Key result
Antioxidant pre-treatment with melatonin or NAC prevented the increase in lipid peroxidation and improved vascular responses to SNP and 5-HT during nitrate tolerance development in rats.
Why the study?
Do antioxidant treatments (NAC or melatonin) prevent the development of nitrate tolerance in normotensive and hypertensive rats?
Do antioxidant treatments (NAC or melatonin) prevent the development of nitrate tolerance in normotensive and hypertensive rats?
Antioxidant therapy may prevent nitrate tolerance by reducing oxidative stress, with differential efficacy depending on the presence of hypertension.
No takes yet. Share an insight, caveat, or question.
Antioxidant pre-treatment may mitigate nitrate tolerance in rats; leaves open clinical translation and requires human trials.
Cabassi et al. (2000) studied Nitrate tolerance. N-acetyl-L-cysteine (NAC) or melatonin vs. Nitrate tolerance without antioxidant pre-treatment was evaluated on Coronary vascular reactivity, lipid peroxidation, and peroxynitrite formation. Antioxidant pre-treatment with melatonin or NAC prevented the increase in lipid peroxidation and improved vascular responses to SNP and 5-HT during nitrate tolerance development in rats.
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