Key result
Continuous warfarin administration during atrial fibrillation ablation reduced symptomatic stroke or TIA compared to heparin bridging (0.15% vs 0.67%; P=0.021) without increasing bleeding.
Why the study?
Does continuous warfarin administration reduce symptomatic stroke or TIA in patients undergoing atrial fibrillation ablation compared to warfarin discontinuation with heparin bridging?
Cohort (n=3,280)
No
Does continuous warfarin administration reduce symptomatic stroke or TIA in patients undergoing atrial fibrillation ablation compared to warfarin discontinuation with heparin bridging?
Absolute Event Rate: 0.15% vs 0.67%
p-value: p=0.021
Continuing warfarin during atrial fibrillation ablation significantly reduces periprocedural stroke or TIA compared to heparin bridging, without increasing the risk of major hemorrhagic complications.
No takes yet. Share an insight, caveat, or question.
May support uninterrupted warfarin to lower periprocedural stroke risk in AF ablation; leaves open need for randomized confirmation.
Kuwahara et al. (2012) conducted a cohort in Atrial fibrillation (n=3,280). Continuous warfarin administration vs. Warfarin discontinuation with heparin bridging was evaluated on Symptomatic stroke or transient ischemic attack (p=0.021). Continuous warfarin administration during atrial fibrillation ablation reduced symptomatic stroke or TIA compared to heparin bridging (0.15% vs 0.67%; P=0.021) without increasing bleeding.
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