Key result
Iron deficiency anemia with hemoglobin 6-9 g/dL was associated with decreased left ventricular global strains compared to healthy controls and milder anemia (p<0.05).
Why the study?
Can 3-dimensional speckle-tracking echocardiography detect left ventricular systolic dysfunction in patients with iron deficiency anemia?
Observational (n=123)
Can 3-dimensional speckle-tracking echocardiography detect left ventricular systolic dysfunction in patients with iron deficiency anemia?
p-value: p=<0.05
3D speckle-tracking echocardiography, particularly global area strain and global longitudinal strain, can sensitively detect early left ventricular remodeling and systolic dysfunction in patients with iron deficiency anemia and hemoglobin levels of 6-9 g/dL.
Associated LV strain reduction in moderate-severe IDA should not change practice; leaves open utility of 3D STE for early detection.
OBJECTIVE: The present study aimed to evaluate left ventricular (LV) systolic function in patients with iron deficiency anemia (IDA) by 3 dimensional speckle-tracking echocardiography (3DSTE). METHODS: Participants were grouped by hemoglobin (Hb) levels in order to study the effect of anemia on cardiac function. Group A included 40 healthy volunteers. Eighty-three patients who were diagnosed with IDA were divided into 2 groups according to the Hb level. Group B (Hb 9 g/dL) included 44 patients, while group C (Hb 6-9 g/dL) included 39 patients. Left ventricular end-diastolic volume (LVEDV), left ventricular endsystolic volume (LVESV), left ventricular mass index (LVMI), and left ventricular ejection fraction (LVEF) were calculated by real-time 3-dimensional echocardiography (RT3D). Left ventricular global longitudinal strain (GLS), global area strain (GAS), global radial strain (GRS), and global circumferential strain (GCS) were obtained by 3DSTE. RESULTS: LVMI, LVEDV and LVESV of group C increased and GCS, GRS, GLS, and GAS of group C decreased compared with those of groups A and B (all p<0.05). GAS and GLS decreased significantly compared with other parameters (both p<0.01). CONCLUSION: LV remodeling and LV systolic dysfunction occurred in patients when the hemoglobin level was in the range of 6-9 g/dL. 3DSTE can evaluate LV systolic function in patients with IDA, and GAS and GLS are more sensitive than other parameters.
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Qiao Zhou (2017) conducted an observational in Iron deficiency anemia (n=123). Severe iron deficiency anemia (Hb 6-9 g/dL) vs. Healthy volunteers and patients with milder anemia was evaluated on Left ventricular systolic function parameters (LVMI, LVEDV, LVESV, GCS, GRS, GLS, GAS) (p=<0.05). Iron deficiency anemia with hemoglobin 6-9 g/dL was associated with decreased left ventricular global strains compared to healthy controls and milder anemia (p<0.05).
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