Stroke and death-findings from a 25-year follow-up of a cohort of employed Swedish middle-aged men of the Coeur study

Aim In 1993, a study of 1000 automotive workers in Sweden and France looked into national differences of cardiovascular disease. Here, we evaluate the proportion of the Swedish cohort that suffered a stroke or died over a 25-year period and associated risk factors. Subject and methods Data from 1993 included a life-style questionnaire, a health examination and laboratory data. Figures on stroke and survival status up until the end of 2018 were collected from national registers. Survival analysis was used for both univariable and multivariable analyses to study associations between potential risk factors and stroke and death, respectively. Results By the end of 2018, 65 individuals had suffered a stroke and 160 had died. In the univariable analysis, we found age, systolic blood pressure, Framingham risk index and diabetes at baseline to be significantly associated with stroke during follow-up. For death, most of the traditional risk factors were significantly associated with the outcome, as was blue-collar work and living alone. In the multivariable analysis, age and diabetes at baseline remained significantly associated with stroke, whereas eight factors (age, blue-collar work, living alone, systolic blood pressure, waist–hip ratio, smoking habits, diabetes and hypertension at baseline) were significantly associated with death during follow-up. Conclusion Few of the traditional risk factors were significantly associated with stroke possibly explained by low power and/or different pathogenetic mechanism than for myocardial infarction. Partly because death occurred more often, we did find a number of potential risk factors to be significantly associated with this outcome.