Long non-coding RNA maternally expressed gene 3 (MEG3) rs4081134 gene polymorphism and preeclampsia risk

Objective: Preeclampsia (PE), a significant challenge for health systems, is a hypertensive disorder of pregnancy. Some studies have suggested that long non-coding ribonucleic acids play a major role in the pathogenesis of PE by regulating the biological behaviors of maternal vascular smooth muscle cells and trophoblasts. In this study, the impact of the maternally expressed gene 3 (MEG3) rs4081134 gene polymorphism on susceptibility to PE has been evaluated. Materials and Methods: We conducted a case-control study comprising 130 PE patients and 140 normotensive pregnant women with normal gestational outcomes. Genotype analysis was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Results: gene. Conclusion: rs4081134 gene polymorphism was significantly associated with newborn's birth weight.