What does this research mean for the field?

Children with sickle cell disease exhibit early glomerular hyperfiltration and tubular dysfunction, with altered uric acid handling serving as an early marker of tubular injury even when serum uric acid levels are normal. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to assess glomerular and tubular function and uric acid handling in children with sickle cell disease.

June 7, 2026Pediatric Hematology Oncology JournalOpen Access

Early Glomerular and Tubular Dysfunction in Children with Sickle Cell Disease

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Authors

HAHala M. AssemAlexandria University DHDonia M.Y. HammadAlexandria University NMNevien L. MikhailAlexandria University

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Implication

Case-control study evaluates kidney function in children with sickle cell disease and highlights early markers of dysfunction.

Key Points

The aim is to assess glomerular and tubular function and uric acid handling in children with sickle cell disease.
Case-control study involving 38 children with sickle cell disease and 38 healthy controls.
Renal evaluation included serum creatinine, BUN, cystatin C, eGFR, urine ACR, urinary β2-microglobulin, UUa/UCr, and FeUA measurements.
Statistical comparisons were made between SCD children and healthy controls.
Children with SCD showed significant renal alterations compared to controls with lower serum creatinine and BUN, and higher cystatin C and eGFR.
Albuminuria was detected in 13.2% of SCD patients, increasing with age, suggesting renal damage.
Signs of tubular dysfunction included reduced urine specific gravity and increased urinary β2-microglobulin.

Cite This Study

Assem et al. (2026) studied this question.

synapsesocial.com/papers/6a250a0b7def13d035e1a5de https://doi.org/10.1016/j.phoj.2026.100841

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Early Glomerular and Tubular Dysfunction in Children with Sickle Cell Disease

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Key Points

Cite This Study

Early Glomerular and Tubular Dysfunction in Children with Sickle Cell Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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