A Young Woman with Recurrent Lymphadenopathy and Fatigue

A young woman with a two-year history of recurrent cervical lymphadenopathy, fatigue, and systemic symptoms underwent an extensive evaluation for infectious, malignant, and autoimmune causes, all of which were unrevealing. Despite persistent symptoms, initial diagnostic frameworks failed to yield a unifying explanation, prompting repeated reassessment and expansion of the differential diagnosis. This case highlights the limitations of exhaustive testing in the absence of diagnostic clarity and underscores the importance of iterative clinical reasoning, diagnostic flexibility, and reconsideration of common conditions presenting in atypical ways.