Key result
Older age (≥65 years) was associated with increased long-term all-cause mortality compared with younger adults (<65 years) among 1,497 patients surviving myocardial infarction.
Why the study?
To compare long-term survival after myocardial infarction between younger and older adults and identify clinical and treatment-related predictors of mortality.
Does younger age compared to older age affect long-term survival in patients surviving acute myocardial infarction?
Cohort (n=1,497)
Yes
Does younger age compared to older age affect long-term survival in patients surviving acute myocardial infarction?
Answers are grounded in this paper and cite their sources.
In patients surviving an acute myocardial infarction, younger age, percutaneous coronary intervention, and evidence-based discharge pharmacotherapy are associated with improved long-term survival.
The aim of the present thesis was to compare long-term survival after myocardial infarction between younger and older adults and to identify clinical and treatment-related predictors of mortality. A retrospective multicentre cohort study was conducted using data from the CardioMining database (Trial registration number NCT05176769). Patients hospitalised with ST-elevation myocardial infarction (STEMI) or non–ST-elevation myocardial infarction (NSTEMI) who survived to discharge were included and were classified as younger or older using a 65-year age cut-off. The primary outcome was all-cause mortality. Survival was analysed using Kaplan–Meier estimates and log-rank tests, while Cox proportional hazards regression models were used to identify independent predictors of mortality. Among 1,497 patients, younger adults were more frequently male, had a higher prevalence of lifestyle-related risk factors and more often presented with STEMI, whereas older patients exhibited a greater burden of comorbidities. Older age was associated with increased mortality, while percutaneous coronary intervention was associated with improved survival. Evidence-based discharge pharmacotherapy was also associated with better survival outcomes. In conclusion, younger adults demonstrated better long-term survival after myocardial infarction compared with older adults, and both invasive management and optimal medical treatment were associated with improved survival.
No takes yet. Share an insight, caveat, or question.
Αναστασία Γ. Χριστοδούλου (2026) conducted a cohort in acute myocardial infarction (n=1,497). Older age (≥65 years) vs. Younger age (<65 years) was evaluated on all-cause mortality. Older age (≥65 years) was associated with increased long-term all-cause mortality compared with younger adults (<65 years) among 1,497 patients surviving myocardial infarction.
Synapse has enriched 10 related papers. Consider them for comparative context: