Why the study?
Youth-onset type 2 diabetes is characterized by early complications including cardiac autonomic neuropathy, and reduced heart rate variability is an early marker of autonomic dysfunction.
Does youth-onset type 2 diabetes reduce heart rate variability and autonomic recovery during submaximal exercise compared to obesity alone?
Population
19 youth-onset type 2 diabetes patients and 6 controls with obesity
Comparison
Youth-onset type 2 diabetes vs controls with obesity
Design
Interim analysis of a prospective study
Follow-up
24-h
Key result
Youth-onset type 2 diabetes was associated with persistently higher heart rate and lower SDNN during exercise recovery compared to controls with obesity (P<0.05).
Authors
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May signal early autonomic impairment in youth-onset type 2 diabetes; leaves open prognostic value and intervention effects.
Observational (n=25)
Does youth-onset type 2 diabetes reduce heart rate variability and autonomic recovery during submaximal exercise compared to obesity alone?
p-value: p=<0.05
Youth-onset type 2 diabetes is associated with reduced post-exercise autonomic recovery compared to obesity alone, indicating early cardiac autonomic dysfunction.
KACKER et al. (2026) conducted an observational in Youth-onset type 2 diabetes (n=25). Youth-onset type 2 diabetes vs. Controls with obesity was evaluated on Heart rate and SDNN over 24-h and during/after submaximal exercise (p=<0.05). Youth-onset type 2 diabetes was associated with persistently higher heart rate and lower SDNN during exercise recovery compared to controls with obesity (P<0.05).
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