What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 diabetes and poor mental health. Intervention: South Asian race/ethnicity vs. White race/ethnicity. Primary outcome: Comorbid T2D and depression (OR 8.3, 95% CI 5.0-13.9).

What does this research mean for the field?

South Asian American and Hispanic individuals have significantly higher odds of experiencing comorbid Type 2 diabetes and mental health disorders, such as depression and anxiety, compared to White individuals. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 7, 2026Diabetes

2780-LB: Co-occurrence of Type 2 Diabetes and Poor Mental Health from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multiethnic Study of Atherosclerosis (MESA) Studies

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Key result

South Asian adults are linked to ~8-fold higher odds of comorbid T2D and depression versus Whites.

OR 8.3
95% CI 5.0-13.9

Why the study?

Comorbidity of type 2 diabetes and poor mental health had not been fully examined among South Asian Americans and other minority racial/ethnic populations.

Population

Adults ≥45 years of age from MESA and MASALA

Comparison

South Asian, Hispanic, Chinese, and Black vs White participants

Design

Cross-sectional analysis of baseline cohort data

Authors

NANAHEED AHMEDNew York Proton Center LWLaura C. WyattNew York Proton Center ABAlain G. BertoniPreventive Cardiology

Discussion

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Implication

May warrant enhanced screening awareness; leaves open longitudinal studies to confirm causality and guide interventions in South Asians.

Key Points

To explore the prevalence and factors associated with comorbidity of type 2 diabetes and poor mental health in South Asian Americans and other minority populations.
Utilized baseline data from MESA and MASALA studies.
Included adults aged 45 and older from diverse racial/ethnic backgrounds.
Applied logistic regression analyses to assess associations between T2D and mental health issues.
South Asian participants had higher odds of comorbidity with T2D and depression (OR 8.3, 95% CI 5.0-13.9) compared to Whites.
Hispanic participants also showed increased odds for T2D and depression (OR 3.3, 95% CI 2.0-5.5).
Other South Asian groups exhibited significant comorbid outcomes compared to Indian participants (OR 3.4, 95% CI 1.4-8.4).

Study Design

Type

Cross-Sectional

Multicenter

Yes

Structured PICO

Population

Adults ≥45 years of age from the MESA and MASALA cohorts, primarily female (52.3%) with a mean age of 61 years, evaluated for the comorbidity of T2D and poor mental health.

Comparator

White participants (for main analysis) and Indian participants (for South Asian subgroup analysis)

Outcome

Comorbid binary outcomes: 1) T2D and depression, 2) T2D and anxiety, and 3) T2D and chronic burden

Main Result

Odds Ratio: 8.3 (95% CI 5–13.9)

South Asian and Hispanic adults have significantly higher odds of comorbid Type 2 diabetes and mental health disorders compared to White adults.

Cite This Study

AHMED et al. (2026) conducted a cross-sectional in Type 2 diabetes and poor mental health. South Asian race/ethnicity vs. White race/ethnicity was evaluated on Comorbid T2D and depression (OR 8.3, 95% CI 5.0-13.9). South Asian adults had significantly higher odds of comorbid T2D and depression compared to White adults (OR 8.3; 95% CI 5.0-13.9), with similar trends observed for anxiety and chronic burden.

synapsesocial.com/papers/6a250baa7def13d035e1bb72 https://doi.org/10.2337/db26-2780-lb

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2780-LB: Co-occurrence of Type 2 Diabetes and Poor Mental Health from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multiethnic Study of Atherosclerosis (MESA) Studies

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

2780-LB: Co-occurrence of Type 2 Diabetes and Poor Mental Health from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multiethnic Study of Atherosclerosis (MESA) Studies

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider