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June 7, 2026Diabetes

Young adult obesity links to large LV mass deviations indicating early subclinical structural remodeling.

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Why the study?

Young-onset T2D and obesity increase cardiovascular risk, but sex differences in early cardiac remodeling remain poorly defined.

Are there sex differences in early cardiac remodeling assessed by CMR in young adults with obesity and Type 2 Diabetes?

Population

14 young women and 23 young men with obesity

Comparison

Females vs males

Design

Cross-sectional study

Key result

Female and male young adults with obesity demonstrated large deviations in LV mass indexed to body surface area (Z=-1.62 and Z=-2.03), indicating early subclinical structural remodeling.

Authors

SPSUNGHO PARKYCYe Ji ChoiSRShivani Ramesh

Discussion

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Overview

Should not yet change practice in young adults with T2D and obesity; hypothesis-generating for prognostic value of early LV mass deviations.

Key Points

  • The study aims to explore sex differences in cardiac remodeling among young adults with type 2 diabetes and obesity.
  • Young women (n=14) and men (n=23) with obesity and type 2 diabetes were recruited.
  • Participants underwent cardiac MRI to evaluate left and right ventricular function and myocardial tissue characteristics.
  • Z-scores were computed using sex-specific reference values from SCMR to identify significant differences.
  • Females showed deviations in left ventricular (LV) end-systolic volume (Z=1.27) and ejection fraction (Z=-1.00).
  • Both sexes exhibited significant deviations in indexed LV mass (females: Z=-1.62, males: Z=-2.03).
  • Sex differences were noted in right ventricular parameters, though within normal ranges.

Study Design

Type

Cross-Sectional (n=37)

Structured PICO

Are there sex differences in early cardiac remodeling assessed by CMR in young adults with obesity and Type 2 Diabetes?

P
Population
37 young adults (14 women, 23 men) with obesity and a high prevalence of Type 2 Diabetes undergoing comprehensive cardiac MRI.
E
Exposure
Cardiac MRI (Philips 3T) assessment
C
Comparator
Sex differences (females vs. males)
O
Outcome
Left and right ventricular size and global function, LV global strain, aortic flow, and myocardial tissue characterization (native T1 and T2* mapping)surrogate

Young adults with obesity and Type 2 Diabetes exhibit early subclinical structural cardiac remodeling, particularly in LV mass indexed to body surface area, which may precede overt functional impairment.

Cite This Study

PARK et al. (2026) conducted a cross-sectional in Type 2 Diabetes and obesity (n=37). Female sex vs. Male sex was evaluated on Cardiac remodeling parameters (Z-scores). Female and male young adults with obesity demonstrated large deviations in LV mass indexed to body surface area (Z=-1.62 and Z=-2.03), indicating early subclinical structural remodeling.

synapsesocial.com/papers/6a250c3b7def13d035e1c3ebhttps://doi.org/10.2337/db26-1419-p
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